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Physiol Behav. 2019 May 15;204:309-323. doi: 10.1016/j.physbeh.2019.03.009. Epub 2019 Mar 12.

Epigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesity.

Author information

1
Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.
2
Departamento de Química e Bioquímica, Laboratório de Bioensaios e Dinâmica Celular, Universidade Estadual Paulista (UNESP), Instituto de Biociências, Campus Botucatu, Botucatu, Brazil.
3
Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil; Programa de Pós-Graduação em Bioquímica, UFSC, Florianópolis, Brazil.
4
Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil. Electronic address: a.latini@ufsc.br.

Abstract

Obesity and metabolic disorders are increasing worldwide and are associated with brain atrophy and dysfunction, which are risk factors for late-onset dementia and Alzheimer's disease. Epidemiological studies demonstrated that changes in lifestyle, including the frequent practice of physical exercise are able to prevent and treat not only obesity/metabolic disorders, but also to improve cognitive function and dementia. Several biochemical pathways and epigenetic mechanisms have been proposed to understand the beneficial effects of physical exercise on cognition. This manuscript revised central ongoing research on epigenetic mechanisms induced by exercise and the beneficial effects on obesity-associated cognitive decline, highlighting potential mechanistic mediators.

KEYWORDS:

BDNF; Cognitive impairment; Epigenetics; Exercise; Gene expression; Obesity

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