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Jpn J Radiol. 2019 May;37(5):371-379. doi: 10.1007/s11604-019-00824-4. Epub 2019 Mar 14.

Imaging findings of mixed connective tissue disease in children and adolescents: a case series.

Author information

1
Department of Diagnostic Imaging, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, ON, Canada. drburcugorkem@gmail.com.
2
Department of Diagnostic Imaging, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
3
Department of Rheumatology, The Hospital for Sick Children, Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.

Abstract

Mixed connective tissue disease (MCTD) is a rare disease in children and adolescents which overlaps features of juvenile idiopathic arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. We have provided an image-based approach for evaluation of MCTD in children and adolescents, outlying the most frequent imaging findings. This approach would aid imagers and clinicians to consider the diagnosis of this rare entity and be able to make an accurate list of differential diagnosis for complex rheumatologic diseases such as MCTD, thus facilitating the ultimate goal of early diagnosis and optimal management of affected children.

KEYWORDS:

Children and adolescents; Differential diagnosis; Imaging; Juvenile idiopathic arthritis; Mixed connective tissue disorder; Polymyositis/dermatomyositis; Systemic lupus erythematosus; Systemic sclerosis

PMID:
30875012
DOI:
10.1007/s11604-019-00824-4
[Indexed for MEDLINE]

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