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Mucosal Immunol. 2019 May;12(3):589-600. doi: 10.1038/s41385-019-0158-0. Epub 2019 Mar 15.

Regulatory cytokine function in the respiratory tract.

Author information

1
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
2
Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, United Kingdom.
3
National Heart and Lung Institute, Imperial College London, London, United Kingdom. c.lloyd@imperial.ac.uk.
4
Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, United Kingdom. c.lloyd@imperial.ac.uk.

Abstract

The respiratory tract is an important site of immune regulation; required to allow protective immunity against pathogens, while minimizing tissue damage and avoiding aberrant inflammatory responses to inhaled allergens. Several cell types work in concert to control pulmonary immune responses and maintain tolerance in the respiratory tract, including regulatory and effector T cells, airway and interstitial macrophages, dendritic cells and the airway epithelium. The cytokines transforming growth factor β, interleukin (IL-) 10, IL-27, and IL-35 are key coordinators of immune regulation in tissues such as the lung. Here, we discuss the role of these cytokines during respiratory infection and allergic airway disease, highlighting the critical importance of cellular source and immunological context for the effects of these cytokines in vivo.

PMID:
30874596
DOI:
10.1038/s41385-019-0158-0
[Indexed for MEDLINE]
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