Format

Send to

Choose Destination
Andrologia. 2019 Mar 15:e13267. doi: 10.1111/and.13267. [Epub ahead of print]

Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia.

Author information

1
Andrology Department, Uromedica Polyclinic, Belgrade, Serbia.
2
Urologic Clinic, Clinical Center of Serbia, Belgrade, Serbia.
3
Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade.
4
Gynecology and Urology, La Sapienza University, Rome, Italy.
5
Innovation-Research and Development, Sigma tau Health Science, Utrecht, The Netherlands.
6
American Center for Reproductive Medicine, Andrology Center, Cleveland, Ohio.

Abstract

Carnitine is essential for energy metabolism and spermatozoa maturation. Combining L-carnitine and L-acetylcarnitine with micronutrients has been investigated as a treatment for infertility in men. We evaluated the effects of a therapeutic formulation, Proxeed Plus, on sperm parameters in oligoasthenozoospermic men. This prospective, randomised, double-blind, placebo-controlled clinical trial involved 175 males (19-44 years) with idiopathic oligoasthenozoospermia who failed to impregnate their partners (12 months). Males received Proxeed Plus or placebo for 3 and 6 months. Sperm volume, progressive motility and vitality significantly (p < 0.001) improved after 6 months compared to baseline. Sperm DNA fragmentation index significantly decreased compared to baseline (p < 0.001) and the 3-month therapy (p = 0.014) in treated men. Increased seminal carnitine and α-glucosidase concentration also positively correlated with improved progressive motility. Decreased DNA fragmentation index was the good predictor of progressive sperm motility >10%, and simultaneous measurement of changes in sperm vitality and DNA fragmentation index gave the highest probability of sperm motility 10% (AUC = 0.924; 95% CI = 0.852-0.996; p < 0.001). Logistic regression analyses revealed DNA fragmentation index decrease as the only independent predictor of sperm motility 10% (OR = 1.106; p = 0.034). We have demonstrated the beneficial effects of carnitine derivatives on progressive motility, vitality and sperm DNA fragmentation. Combining metabolic and micronutritive factors is beneficial for male infertility.

KEYWORDS:

L-acetylcarnitine; L-carnitine; male infertility; oligoasthenozoospermia; sperm parameters

PMID:
30873633
DOI:
10.1111/and.13267

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center