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Drugs Context. 2019 Mar 6;8:212553. doi: 10.7573/dic.212553. eCollection 2019.

The therapeutic role of minocycline in Parkinson's disease.

Author information

1
Department of Neurology, Faculty of Medicine, Alaaddin Keykubat University, Alanya, Turkey.
2
Department of Anesthesiology and Reanimation, Marmara University Pendik Education and Research Hospital, Istanbul, Turkey.
3
Department of Medical Biology, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey.
4
Department of Medical Physiology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey.

Abstract

Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline may have some neuroprotective activity in various experimental models such as cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, Parkinson's disease (PD), Huntington's disease, and multiple sclerosis. In this perspective review, we summarize the preclinical and clinical findings suggesting the neuroprotective role of minocycline in PD.

KEYWORDS:

Parkinson’s disease; minocycline; neurodegeneration; neuroprotection

Conflict of interest statement

Disclosure and potential conflicts of interest: The authors declare that they have no conflicts of interest. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors are available for download at http://www.drugsincontext.com/wp-content/uploads/2019/02/dic.212553-COI.pdf

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