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Pulm Pharmacol Ther. 2019 Jun;56:79-85. doi: 10.1016/j.pupt.2019.03.003. Epub 2019 Mar 11.

Antitussive therapy: A role for levodropropizine.

Author information

Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, Department of Respiratory Medicine, King's College Hospital, London, United Kingdom. Electronic address:
Respiratory Medicine and Pulmonary Rehabilitation Section, Clinic Center, Private Hospital, Naples, Italy. Electronic address:
Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA. Electronic address:
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. Electronic address:
Medical Department, Dompé Farmaceutici S.p.A., Milan, Italy. Electronic address:
Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK. Electronic address:
Medical Department, Dompé Farmaceutici S.p.A., Via Santa Lucia, 6, 20122, Milan, Italy. Electronic address:
S.I.S.Me.R. Società Italiana Studi di Medicina della Riproduzione, Bologna, Italy. Electronic address:


Cough is a protective reflex that serves to clear the airways of excessive secretions and foreign matter and which sometimes becomes excessive, and troublesome to patients. Cough is one of the most common reasons why individuals seek medical attention. A range of drugs have been developed in the past with antitussive activity and different mechanisms of action, but there are still very few safe and effective treatments available. The poor tolerability of most available antitussives is closely related to their action on the central nervous system (CNS). An international group of experts specialized in cough met to discuss the need to identify an effective antitussive treatment with a good tolerability profile. The aim of this expert review is to increase the knowledge about the cough mechanism and the activity of levodropropizine, a peripherally acting antitussive drug.


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