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Int J Mol Sci. 2019 Mar 12;20(5). pii: E1239. doi: 10.3390/ijms20051239.

The Role of Curcumin in the Modulation of Ageing.

Author information

1
Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland. a.bielak@nencki.gov.pl.
2
Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland. w.grabowska@nencki.gov.pl.
3
Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland. a.ciolko@nencki.gov.pl.
4
Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland. a.bojko@nencki.gov.pl.
5
Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland. g.mosieniak@nencki.gov.pl.
6
Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland. l.bijoch@nencki.gov.pl.
7
Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland. e.sikora@nencki.gov.pl.

Abstract

It is believed that postponing ageing is more effective and less expensive than the treatment of particular age-related diseases. Compounds which could delay symptoms of ageing, especially natural products present in a daily diet, are intensively studied. One of them is curcumin. It causes the elongation of the lifespan of model organisms, alleviates ageing symptoms and postpones the progression of age-related diseases in which cellular senescence is directly involved. It has been demonstrated that the elimination of senescent cells significantly improves the quality of life of mice. There is a continuous search for compounds, named senolytic drugs, that selectively eliminate senescent cells from organisms. In this paper, we endeavor to review the current knowledge about the anti-ageing role of curcumin and discuss its senolytic potential.

KEYWORDS:

ageing; anti-cancer; autophagy; microbiota; senescence; senolytics

PMID:
30871021
PMCID:
PMC6429134
DOI:
10.3390/ijms20051239
[Indexed for MEDLINE]
Free PMC Article

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