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Am J Transplant. 2019 Mar 14. doi: 10.1111/ajt.15350. [Epub ahead of print]

Chronic pain following laparoscopic living-donor nephrectomy: Prevalence and impact on quality of life.

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Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, The Netherlands.
Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Anaesthesiology, Radboud University Medical Center , Nijmegen, The Netherlands.


Chronic postsurgical pain (CPSP) following laparoscopic donor nephrectomy (LDN) is a disregarded topic. In this cross-sectional study, all consecutive patients who underwent an LDN at the Radboud University Medical Center (Radboudumc; 2003-2016) were approached for participation. Five hundred twelve living kidney donors were included and asked to complete two questionnaires, including the McGill Pain Questionnaire and the RAND Short Form-36 Health Status Inventory (RAND SF-36) regarding their health-related quality of life (HRQoL). The mean prevalence of CPSP following LDN was 5.7%, with a mean follow-up time of 6 years. Possible predictors of CPSP following LDN are severe early postoperative pain, previous abdominal surgery, and preexisting backache. The RAND SF-36 revealed an impaired HRQoL in patients with CPSP when compared to patients without CPSP. In conclusion, this study revealed that the prevalence of CPSP following LDN is substantial. Given the possible association between the presence of CPSP and impaired HRQoL scores, living kidney donors should be well informed in the preoperative phase about the risk of CPSP.


anesthesia/pain management; clinical research/practice; donor follow-up; donors and donation; kidney transplantation; kidney transplantation/nephrology; living donor; patient safety; quality of life (QoL)


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