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Naunyn Schmiedebergs Arch Pharmacol. 2019 Mar 13. doi: 10.1007/s00210-019-01643-0. [Epub ahead of print]

The antiobese effect of AT1 receptor blockade is augmented in mice lacking Mas.

Author information

1
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.
2
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany.
3
Department for Radiology and Nuclear Medicine, University of Lübeck, Lübeck, Germany.
4
Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.
5
National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
6
DZHK (German Centre for Cardiovascular Research), partner site, Berlin, Germany.
7
Center for Structural and Cell Biology in Medicine, Institute for Biology, University of Lübeck, Lübeck, Germany.
8
Charité - University Medicine Berlin, Berlin, Germany.
9
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. walter.raasch@pharma.uni-luebeck.de.
10
CBBM (Center of Brain, Behavior and Metabolism), Lübeck, Germany. walter.raasch@pharma.uni-luebeck.de.
11
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany. walter.raasch@pharma.uni-luebeck.de.

Abstract

We recently showed that the antiobese efficacy of the AT1 receptor blocker telmisartan (TEL) is at least partially related to an Ang(1-7)-dependent mechanism. Ang(1-7) acts via Mas, thus raising the question of whether Mas-deficient (Mas-ko) mice are likewise predisposed to develop diet-induced obesity and, further, whether this can be prevented by TEL treatment. Mas-ko mice and FVB/N wild-type (wt) animals were treated with TEL (8 mg/kg/day) or vehicle while they were fed with high-fat diet (HFD) or chow. Mice were phenotyped regarding body weight, fat mass, insulin sensitivity, and leptin sensitivity. In response to HFD feeding, gain in body weight and impairment of leptin sensitivity were similar between wt and Mas-ko mice. TEL reduced body weight in both strains but effects were stronger in Mas-ko mice. TEL diminished fat mass and restored leptin sensitivity only in Mas-ko mice. Blood glucose was higher in wt than Mas-ko mice fed with HFD while not differing when they were fed with chow. Insulin challenge confirmed that wt mice became insulin resistant when fed with HFD while HFD feeding did not impair insulin sensitivity in Mas-ko mice. TEL had no further effect. Our findings on the influence of TEL on growth and metabolism in Mas-ko mice conflict with our previous findings in rats. We assume that the FVB/N background of the mice may partly explain these inconsistent data. Moreover, it also seems feasible that the MrgD receptor compensates for Mas deficiency.

KEYWORDS:

Angiotensins; Antiobese; Mas-ko mice

PMID:
30868173
DOI:
10.1007/s00210-019-01643-0

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