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Mutat Res. 1986 Jun;174(2):85-8.

Mutagenic activation of aflatoxin B1 by several forms of purified cytochrome P-450.

Abstract

Metabolic activation by several forms of purified cytochrome P-450 of aflatoxin B1 to a product(s) mutagenic to Salmonella typhimurium TA100 was examined. Of the 5 forms of cytochrome P-450 purified from liver microsomes of untreated and PCB-treated male rats, a constitutive form purified from untreated male rats, P-450-male, and a high-spin form of cytochrome P-450, P-448-H, from PCB-treated rats were highly active.

PMID:
3086716
DOI:
10.1016/0165-7992(86)90095-3
[Indexed for MEDLINE]

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