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Am J Perinatol. 2019 Mar 13. doi: 10.1055/s-0039-1683438. [Epub ahead of print]

The Effect of Antenatal Vaginal Progesterone Administration on Uterine, Umbilical, and Fetal Middle Cerebral Artery Doppler Flow: A Cohort Study.

Author information

1
Department of Obstetrics and Gynecology, Kasr Alainy Hospital, Cairo University, Cairo, Egypt.
2
Department of Obstetrics and Gynecology, Minia University, Minia, Egypt.
3
Department of Gynecology and Obstetrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
4
Department of Gynecology and Obstetrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Abstract

OBJECTIVE:

 To evaluate the effect of vaginal progesterone (P) administration during the second and third trimesters of pregnancy on Doppler velocimetry of uterine, umbilical, and middle cerebral vessels.

STUDY DESIGN:

 A prospective cohort study conducted on 80 women at risk for preterm labor. Uterine artery, umbilical artery, and middle cerebral artery (MCA) Doppler indices were measured before and after 1 week of administration of 200 mg twice daily vaginal P. The primary outcome parameter was the change of MCA pulsatility index (PI) after P administration. Secondary outcomes included changes in uterine artery and umbilical artery Doppler measurement.

RESULTS:

 There was no significant changes of umbilical artery resistance index (RI) (0.69 ± 0.049 vs. 0.68 ± 0.041), umbilical artery PI (1.14 ± 0.118 vs. 1.11 ± 0.116), uterine artery RI (0.66 ± 0.12 vs. 0.66 ± 0.107), uterine artery PI (1.00 ± 0.26 vs. 1.016 ± 0.24), and MCA PI (1.27 ± 0.18 vs. 1.26 ± 0.23) measurements before and after 1 week of P administration, respectively.

CONCLUSION:

 Vaginal P has no significant effects on uterine artery, umbilical artery, and MCA Doppler indices.

SYNOPSIS:

 Administration of vaginal P has no significant effects on uterine artery, umbilical artery, and MCA Doppler indices.

CLINICAL TRIAL:

 Clinical trial registration number is ClinicalTrials.gov IDNCT03292939.

PMID:
30866028
DOI:
10.1055/s-0039-1683438

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