Cortical State Fluctuations across Layers of V1 during Visual Spatial Perception

Anderson Speed; Joseph Del Rosario; Christopher P Burgess; Bilal Haider

doi:10.1016/j.celrep.2019.02.045

Cortical State Fluctuations across Layers of V1 during Visual Spatial Perception

Cell Rep. 2019 Mar 12;26(11):2868-2874.e3. doi: 10.1016/j.celrep.2019.02.045.

Authors

Anderson Speed¹, Joseph Del Rosario¹, Christopher P Burgess², Bilal Haider³

Affiliations

¹ Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
² University College London, Gower Street, London WC1E 6BT, UK.
³ Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA. Electronic address: bilal.haider@bme.gatech.edu.

Abstract

Many factors modulate the state of cortical activity, but the importance of cortical state variability for sensory perception remains debated. We trained mice to detect spatially localized visual stimuli and simultaneously measured local field potentials and excitatory and inhibitory neuron populations across layers of primary visual cortex (V1). Cortical states with low spontaneous firing and correlations in excitatory neurons, and suppression of 3- to 7-Hz oscillations in layer 4, accurately predicted single-trial visual detection. Our results show that cortical states exert strong effects at the initial stage of cortical processing in V1 and can play a prominent role for visual spatial behavior in mice.

Keywords: correlations; inhibitory neurons; mouse behavior; oscillations; visual cortex.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Gamma Rhythm
Male
Mice
Mice, Inbred C57BL
Neurons / physiology
Space Perception*
Visual Cortex / cytology
Visual Cortex / physiology*

Abstract

Publication types

MeSH terms

Grants and funding