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Endocr Pract. 2019 Mar 13. doi: 10.4158/EP-2018-0547. [Epub ahead of print]

CRYOPRESERVATION OF PARATHYROID TISSUE: A WHITE PAPER ON ESTABLISHING A LOCAL SERVICE.

Author information

1
From: 1Department of Endocrine Surgery, Endocrinology and Metabolism Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland.
2
Andrology Laboratory and Sperm Bank, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland.

Abstract

OBJECTIVES:

Preservation of parathyroid function is one of the primary tenets of endocrine surgery. For patients with thyroid disease, an inadvertently compromised parathyroid gland is routinely auto transplanted into the neck at the time of surgery. By contrast for patients with parathyroid disease secondary to hyperplasia, the timing of auto transplantation needs to be further considered in order to balance the risks between persistent disease and permanent hypocalcaemia. Cryopreservation preserves cellular function and permits the storage of parathyroid tissue for potential re-implantation at a later date, in patients who develop hypoparathyroidism.

METHODS:

In this paper we review the process of cryopreservation, with particular emphasis on the regulatory issues involved in establishing a local service, tissue processing, billing and reimbursements, outcome (functionality) and complications.

RESULTS:

A detailed description of the technique as performed at our institution is described and illustrated.

CONCLUSIONS:

Cryopreservation affords surgical insurance against the disastrous sequelae of permanent hypoparathyroidism. Our techniques are easy to adopt with only a modest initial investment of time and money, particularly for institutions that already cryopreserve other tissue types.

PMID:
30865532
DOI:
10.4158/EP-2018-0547

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