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J Exp Med. 1986 Jun 1;163(6):1595-600.

Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.

Abstract

Human endothelial cells activated with IL-1 express a surface membrane-oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury.

PMID:
3086483
PMCID:
PMC2188126
[Indexed for MEDLINE]
Free PMC Article
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