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J Diabetes. 2019 Mar 13. doi: 10.1111/1753-0407.12915. [Epub ahead of print]

Current understanding of the role of gut dysbiosis in type 1 diabetes.

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Department of Surgery-Transplant, University of Nebraska Medical Center, Omaha, NE, United States.
Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, United States.
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Mansoura, Egypt.


Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from destruction of the insulin producing pancreatic β-cells. The disease mainly affects juveniles. Alterations in the composition of gut microbiota (dysbiosis) and changes in properties of the gut barrier have been documented in T1D subjects. Since these factors affect immune system functions, they are likely to play a role in disease pathogenesis. However, their exact role is currently not fully understood and is under intensive investigation. In this article, we discuss recent advancements depicting the role of intestinal dysbiosis on immunity and autoimmunity in T1D. We also discuss therapies aimed at maintaining a healthy gut barrier as prevention strategies for T1D.


autoimmunity; dysbiosis; gut barrier; microbiome; type 1 diabetes


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