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Sci Rep. 2019 Mar 12;9(1):4223. doi: 10.1038/s41598-019-40710-7.

Measurement of Glomerular Filtration Rate using Quantitative SPECT/CT and Deep-learning-based Kidney Segmentation.

Park J1,2, Bae S2,3, Seo S4, Park S5, Bang JI6, Han JH3, Lee WW7,8,9, Lee JS10,11,12.

Author information

1
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
2
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
3
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
4
Department of Neuroscience, College of Medicine, Gachon University, Incheon, Korea.
5
Department of Nuclear Medicine, National Cancer Center, Goyang-si, Gyeonggi-do, Korea.
6
Department of Nuclear Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
7
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. wwlee@snu.ac.kr.
8
Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea. wwlee@snu.ac.kr.
9
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea. wwlee@snu.ac.kr.
10
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea. jaes@snu.ac.kr.
11
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea. jaes@snu.ac.kr.
12
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea. jaes@snu.ac.kr.

Abstract

Quantitative SPECT/CT is potentially useful for more accurate and reliable measurement of glomerular filtration rate (GFR) than conventional planar scintigraphy. However, manual drawing of a volume of interest (VOI) on renal parenchyma in CT images is a labor-intensive and time-consuming task. The aim of this study is to develop a fully automated GFR quantification method based on a deep learning approach to the 3D segmentation of kidney parenchyma in CT. We automatically segmented the kidneys in CT images using the proposed method with remarkably high Dice similarity coefficient relative to the manual segmentation (mean = 0.89). The GFR values derived using manual and automatic segmentation methods were strongly correlated (R2 = 0.96). The absolute difference between the individual GFR values using manual and automatic methods was only 2.90%. Moreover, the two segmentation methods had comparable performance in the urolithiasis patients and kidney donors. Furthermore, both segmentation modalities showed significantly decreased individual GFR in symptomatic kidneys compared with the normal or asymptomatic kidney groups. The proposed approach enables fast and accurate GFR measurement.

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