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Cancer Discov. 2019 Apr;9(4):476-481. doi: 10.1158/2159-8290.CD-18-1357. Epub 2019 Mar 12.

Cancer Vaccines: Steering T Cells Down the Right Path to Eradicate Tumors.

Ott PA1,2,3,4, Wu CJ5,6,7,8.

Author information

1
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
2
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
3
Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
4
Harvard Medical School, Boston, Massachusetts.
5
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. cwu@partners.org.
6
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. cwu@partners.org.
7
Broad Institute of MIT and Harvard, Cambridge, Massachusetts. cwu@partners.org.
8
Harvard Medical School, Boston, Massachusetts. cwu@partners.org.

Abstract

Lack of tumor T-cell infiltration is a barrier to the efficacy of immune checkpoint inhibitors and other immunotherapies in patients with cancer. Because of their ability to activate and augment tumor-specific T cells, vaccines are an attractive approach to direct T-cell responses into the tumor.

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