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Euro Surveill. 2019 Mar;24(10). doi: 10.2807/1560-7917.ES.2019.24.10.1900147.

Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018.

Author information

1
Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
2
Big Data Institute, University of Oxford, Oxford, United Kingdom.
3
National Incident Management Team, Public Health England, London, United Kingdom.
4
These authors contributed equally to this work.
5
Population Health Sciences, University of Bristol, Bristol, United Kingdom.

Abstract

We describe detection in the United Kingdom (UK) of the drug-resistant Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance. Two female patients developed infection following contact with UK-resident men from the same sexual network linked to travel to Ibiza, Spain. One case failed treatment with ceftriaxone, and azithromycin and gentamicin, before successful treatment with ertapenem. Both isolates had indistinguishable whole-genome sequences. Urgent action is essential to contain this drug-resistant strain.

KEYWORDS:

antimicrobial resistance; antimicrobial treatment; gonorrhoeae; treatment failure; whole-genome sequencing

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