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Basic Clin Pharmacol Toxicol. 2019 Mar 12. doi: 10.1111/bcpt.13225. [Epub ahead of print]

Immunological and pathological effects of E-cigarettes.

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School of Life Sciences, University of Nottingham, Nottingham, UK.


Electronic cigarettes (E-cigarettes) are considered a preferable alternative to conventional cigarettes due to the lack of combustion and the absence of tobacco-specific toxicants. E-cigarettes have rapidly gained in popularity in recent years amongst both existing smokers and previous non-smokers. However, a growing literature demonstrates that E-cigarettes are not as safe as generally believed. Here, we discuss the immunological, and other, deleterious effects of E-cigarettes on a variety of cell types and host defence mechanisms in humans and in murine models. We review not only the effects of complete E-cigarette liquids, but also each of the main components - nicotine, humectants and flavourings. This MiniReview thus highlights the possible role of E-cigarettes in the pathogenesis of disease and raises awareness of the potential harm that E-cigarettes may cause. This article is protected by copyright. All rights reserved.


E-cigarette; flavourings; humectants; immunological effects; nicotine; tobacco


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