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Dev Cell. 2019 Mar 11;48(5):595-596. doi: 10.1016/j.devcel.2019.02.017.

Embryonic Immune Cells Remodel the Heart.

Author information

1
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: sgrainger@ucsd.edu.
2
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: dtraver@ucsd.edu.

Abstract

How the products of transient hematopoiesis in the yolk sac, dorsal aorta, and developing heart tube function at their sites of production is poorly understood. In this issue of Developmental Cell, Shigeta et al. (2019) elegantly demonstrate that macrophages derived from the heart tube contribute to local tissue remodeling during valve development.

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