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Clin Infect Dis. 2019 Mar 6. pii: ciz172. doi: 10.1093/cid/ciz172. [Epub ahead of print]

Loa loa microfilariae in skin snips: consequences for onchocerciasis monitoring and evaluation in L. loa endemic areas.

Author information

1
Centre for Research on Filariasis and other Tropical Diseases, Yaounde Cameroon.
2
IRD UMI 233-INSERM U1175-Montpellier University, Montpellier, France.
3
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
4
Neglected Tropical Diseases Support Center (NTDSC), Task Force for Global Health, Decatur, Atlanta, GA, USA.
5
Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde Cameroon.

Abstract

The specificity of skin snips for onchocerciasis diagnosis is considered to be almost 100%. In this study, molecular methods revealed that microfilariae emerging from skin snips collected from highly microfilaremic Loa loa-infected individuals were largely misidentified as Onchocerca volvulus. This has important implications for onchocerciasis diagnostic testing in Loa-endemic areas.

KEYWORDS:

Loa loa ; Onchocerca volvulus ; Skin snip; diagnosis; filariasis

PMID:
30861060
DOI:
10.1093/cid/ciz172

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