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Med Phys. 2019 May;46(5):2522-2525. doi: 10.1002/mp.13474. Epub 2019 Mar 22.

Technical Note: A new method to rapidly identify benign and malignant breast lumps through bioelectrical impedance spectroscopy.

Author information

1
Department of Breast Thyroid Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
2
Department of pathology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.

Abstract

PURPOSE:

To evaluate the effectiveness of Bioelectrical Impedance Spectroscopy (BIS) in order to rapidly distinguish malignant vs benign breast masses.

METHODS:

A total of 622 breast masses from 489 patients were collected from January 2015 to June 2017. Every specimen was evaluated by a breast tissue bioimpedance analyzer (MScan1.0B) followed by morphological examination by pathologists. The results from BIS were compared with the morphological results from pathology (as a gold standard). The specificity and sensitivity of BIS were evaluated and the consistency test was performed.

RESULTS:

Compared with the pathology standard, BIS had good sensitivity (92.4%), specificity (96.0%), false positive rate (3.96%), and false negative rate (7.58%). The positive likelihood ratio, negative likelihood ratio, positive predictive value, and negative predictive values of BIS were 23.36, 0.0789, 73.49%, 99.07%, respectively. The kappa value of BIS was 0.794 ± 0.038 in the consistency test.

CONCLUSION:

Compared with the pathology standard, the BIS is an effective, convenient, and economical detection method to quickly differentiate benign and malignant breast masses with high accuracy. It may serve as a potential supplement of intraoperative pathological examinations.

KEYWORDS:

bioelectrical impedance spectroscopy; breast neoplasm; intraoperative detection; pathological examination

PMID:
30859583
DOI:
10.1002/mp.13474

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