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Nat Commun. 2019 Mar 11;10(1):1168. doi: 10.1038/s41467-019-09091-3.

Human olfactory-auditory integration requires phase synchrony between sensory cortices.

Author information

1
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. guangyu.zhou@northwestern.edu.
2
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
3
Department of Psychology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
4
Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
5
Department of Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
6
Department of Psychology, Stockholm University, SE-106 91, Stockholm, Sweden.
7
Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York, NY, 10016, USA.
8
Department of Neuroscience and Physiology, New York University, New York, NY, 10016, USA.
9
Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. c-zelano@northwestern.edu.

Abstract

Multisensory integration is particularly important in the human olfactory system, which is highly dependent on non-olfactory cues, yet its underlying neural mechanisms are not well understood. In this study, we use intracranial electroencephalography techniques to record neural activity in auditory and olfactory cortices during an auditory-olfactory matching task. Spoken cues evoke phase locking between low frequency oscillations in auditory and olfactory cortices prior to odor arrival. This phase synchrony occurs only when the participant's later response is correct. Furthermore, the phase of low frequency oscillations in both auditory and olfactory cortical areas couples to the amplitude of high-frequency oscillations in olfactory cortex during correct trials. These findings suggest that phase synchrony is a fundamental mechanism for integrating cross-modal odor processing and highlight an important role for primary olfactory cortical areas in multisensory integration with the olfactory system.

PMID:
30858379
PMCID:
PMC6411726
DOI:
10.1038/s41467-019-09091-3
[Indexed for MEDLINE]
Free PMC Article

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