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J Bacteriol. 2019 Mar 11. pii: JB.00150-19. doi: 10.1128/JB.00150-19. [Epub ahead of print]

Onwards and [K+]upwards: a new potassium importer under the spell of cyclic-di-AMP.

Author information

1
School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia.
2
The University of Danang, University of Science and Technology, Da Nang, Vietnam.
3
School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia m.turner2@uq.edu.au.
4
Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Brisbane, Queensland, Australia.

Abstract

Cyclic diadenosine monophosphate (c-di-AMP) is a second messenger which plays a major role in osmotic homeostasis in bacteria. In the work of Quintana et al. (J Bacteriol DOI: 10.1128/JB.00028-19) two Kup homologs from Lactococcus lactis were identified as high affinity K+ importers whose activity is inhibited by direct binding of c-di-AMP. The results broaden the scope of K+ level regulation by c-di-AMP with Kup homologs found in a number of pathogenic, commensal and industrial bacteria.

PMID:
30858295
DOI:
10.1128/JB.00150-19

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