Format

Send to

Choose Destination
Development. 2019 Mar 11;146(5). pii: dev169821. doi: 10.1242/dev.169821.

The diverse neural crest: from embryology to human pathology.

Author information

1
Aix-Marseille Université, INSERM, MMG, U1251, 27 boulevard Jean Moulin 13005 Marseille, France nicole.ledouarin@academie-sciences.fr heather.etchevers@inserm.fr.
2
Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.
3
Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France nicole.ledouarin@academie-sciences.fr heather.etchevers@inserm.fr.

Abstract

We review here some of the historical highlights in exploratory studies of the vertebrate embryonic structure known as the neural crest. The study of the molecular properties of the cells that it produces, their migratory capacities and plasticity, and the still-growing list of tissues that depend on their presence for form and function, continue to enrich our understanding of congenital malformations, paediatric cancers and evolutionary biology. Developmental biology has been key to our understanding of the neural crest, starting with the early days of experimental embryology and through to today, when increasingly powerful technologies contribute to further insight into this fascinating vertebrate cell population.

KEYWORDS:

Cell fate; Neural crest; Neurocristopathies; Vertebrate embryo

PMID:
30858200
DOI:
10.1242/dev.169821
Free full text

Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

Publication type

Publication type

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center