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Peptides. 2019 May;115:43-50. doi: 10.1016/j.peptides.2019.02.009. Epub 2019 Mar 8.

Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch.

Author information

1
Medical College, Henan University of Science and Technology, Luoyang, 471003, China. Electronic address: sui_feng5217@126.com.
2
Medical College, Henan University of Science and Technology, Luoyang, 471003, China.

Abstract

The scorpion Buthus martensii Karsch (BmK) has generated significant interest due to the presence of biologically active peptides in its venom. In the past decade, dozens of different peptides from BmK have been identified. Most of the peptides are neurotoxins and are responsible for the toxicity of BmK venom. Other peptides, including neurotoxins and non-disulfide-bridged peptides, show potential anticancer, antimicrobial, analgesic, and anti-epileptic therapeutic effects. These peptides are attractive candidates for drug development, and peptide derivatives have also been designed to enhance their therapeutic potential, such as ADWX-1 and Kn2-7. In this review, we provide an overview of the most promising peptides found in BmK venom and of modified peptide derivatives showing therapeutic potential.

KEYWORDS:

Buthus martensii Karsch; Peptides; Scorpion; Therapeutic potential

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