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J Comp Eff Res. 2019 Apr;8(6):431-440. doi: 10.2217/cer-2018-0085. Epub 2019 Mar 11.

Impact of selective serotonin reuptake inhibitors in the veteran population: 10-year risk outcomes.

Author information

1
Department of Healthcare Leadership & Management, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA.
2
Research Service, Ralph H. Johnson VA Medical Center (RHJVAMC), Charleston, SC 29401, USA.
3
Department of Otolaryngology Head & Neck Surgery, MUSC, Charleston, SC 29425, USA.
4
Pharmacy Service, RHJVAMC, Charleston, SC 29425, USA.
5
Department of Pathology & Laboratory Medicine, MUSC, Charleston, SC 29425, USA.

Abstract

AIM:

To evaluate the comparative risk of hip fracture or osteoporosis among US Veterans based on selective serotonin reuptake inhibitor (SSRI) exposure.

PATIENTS & METHODS:

A retrospective cohort study of eligible US Veterans Health Administration patients enrolled in 2003-2004 was performed to examine SSRIs' 2-, 5- and 10-year impact on bone health using multiple logistic regression.

RESULTS:

Veterans on SSRIs were found to be 56.7% more likely over a 10-year period to suffer a hip fracture (risk ratio: 1.567; 95% CI: 1.464-1.676) and 34.6% more likely to develop osteoporosis (risk ratio: 1.346; 95% CI: 1.319-1.374) when compared with those who were SSRI naive.

CONCLUSION:

SSRI usage was associated with greater risk of hip fracture and osteoporosis over a 10-year period in the veteran population, with similar effect sizes to smaller studies.

KEYWORDS:

SSRIs; citalopram; comparative risk; escitalopram; fluoxetine; fluvoxamine; fracture risk; paroxetine; risk factor; sertraline

PMID:
30855179
DOI:
10.2217/cer-2018-0085

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