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Endocr Metab Immune Disord Drug Targets. 2019 Mar 11. doi: 10.2174/1871530319666190311141855. [Epub ahead of print]

Correlations between Alzheimer's disease and type 2 diabetes: focus on.

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Unit of Internal Medicine and Geriatrics-Unit of Diabetology, "S. Giovanni Evangelista" Hospital, Via Parrozzani 3, 00019, Tivoli (RM). Italy.
Endocrinologist. Viale dei Colli Portuensi 442, 00151, Roma. Italy.
Unit of Internal Medicine, RM6 Hospital, Roma. Italy.
Interdisciplinary Department of Medicine-Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases. University of Bari "Aldo Moro", School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari. Italy.
Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", School of Medicine, Policlinico, Piazza Giulio Cesare 11, 70124 Bari. Italy.


Background In the last decades both diabetes mellitus and Alzheimer's disease are constantly increasing. Affected individuals, therefore, represent an enormous problem for society, governments and global organizations. These diseases are usually considered as independent conditions, but increasing evidence shows that there are links between these two disorders.


In this review, we analyzed common features present in Alzheimer's disease and diabetes mellitus, showing how these two diseases are strictly correlated each other.


Some pathogenetic factors are shared by Type 2 Diabetes and Alzheimer's Disease: chronic inflammation, oxidative stress, mitochondrial dysfunction, adiponectin deficiency, different expression of plasma cholinesterase activity and vascular damage could represent a possible explanation for the coexistence of these two conditions in many patients.


A better understand of this issue and an appropriate management of diabetes by means of physical activity, low fat diet, and drugs to achieve a good glycemic control, avoiding both hyperglycemia and hypoglycemia, can represent a way to prevent cognitive decline and Alzheimer's disease.


Alzheimer’s disease; Chronic Inflammation; Hyperglycemia; Insulin resistance; Neurodegenerative disorder.; Type 2 diabetes mellitus

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