Send to

Choose Destination
Front Neuroanat. 2019 Feb 22;13:22. doi: 10.3389/fnana.2019.00022. eCollection 2019.

Resting State Functional Connectivity of the Rat Claustrum.

Author information

Center to Advance Chronic Pain Research, Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD, United States.
Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD, United States.
Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD, United States.
Graduate Entry Medicine Program, Monash Rural Health-Churchill, Churchill, VIC, Australia.
Department of Physiology, Monash University, Clayton, VIC, Australia.


The claustrum is structurally connected with many cortical areas.A major hurdle standing in the way of understanding claustrum function is the difficulty in assessing the global functional connectivity (FC) of this structure. The primary issues lie in the inability to isolate claustrum signal from the adjacent insular cortex (Ins), caudate/putamen (CPu), and endopiriform nucleus (Endo). To address this issue, we used (7T) fMRI in the rat and describe a novel analytic method to study claustrum without signal contamination from the surrounding structures. Using this approach, we acquired claustrum signal distinct from Ins, CPu, and Endo, and used this claustrum signal to determine whole brain resting state functional connectivity (RSFC). Claustrum RSFC was distinct from the adjacent structures and displayed extensive connections with sensory cortices and the cingulate cortex, consistent with known structural connectivity of the claustrum. These results suggest fMRI and improved analysis can be combined to accurately assay claustrum function.


anterior cingulate cortex; caudate; cortex; forebrain; insula; putamen; striatum; top-down

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center