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Alzheimers Dement. 2019 May;15(5):675-685. doi: 10.1016/j.jalz.2018.12.016. Epub 2019 Mar 8.

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease.

Author information

1
Department of Radiology, Mayo Clinic, Rochester MN, USA. Electronic address: Whitwell.jennifer@mayo.edu.
2
Department of Health Science Research, Mayo Clinic, Rochester MN, USA.
3
Department of Neurology, Mayo Clinic, Rochester MN, USA.
4
Department of Psychology and Psychiatry, Mayo Clinic, Rochester MN, USA.
5
Department of Radiology, Mayo Clinic, Rochester MN, USA; Department of Information Technology, Mayo Clinic, Rochester MN, USA.
6
Department of Radiology, Mayo Clinic, Rochester MN, USA.

Abstract

INTRODUCTION:

Little is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer's disease (AD).

METHODS:

Regional tau and β-amyloid positron emission tomography standard uptake value ratios and gray matter volumes were calculated in a cohort of 42 participants with atypical AD. The relationship between regional metrics and age was modeled using a Bayesian hierarchical linear model.

RESULTS:

Age was strongly associated with tau uptake across all cortical regions, particularly parietal, with greater uptake in younger participants. Younger age was associated with smaller parietal and lateral temporal volumes. Regional β-amyloid differed little by age. Age showed a stronger association with tau than volume and β-amyloid in all cortical regions. Age was not associated with cognitive performance.

DISCUSSION:

Age is an important determinant of severity of cortical tau uptake in atypical AD, with young participants more likely to show widespread and severe cortical tau uptake.

KEYWORDS:

AV-1451; Amyloid; Magnetic resonance imaging; Pittsburgh compound B; Positron emission tomography; age; tau

PMID:
30853465
PMCID:
PMC6511453
[Available on 2020-05-01]
DOI:
10.1016/j.jalz.2018.12.016

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