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Clin Chim Acta. 2019 Jun;493:138-147. doi: 10.1016/j.cca.2019.03.008. Epub 2019 Mar 8.

Point of care testing for infectious diseases.

Author information

1
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
2
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: Ping.Wang2@uphs.upenn.edu.

Abstract

Infectious diseases are caused by pathogenic microorganisms and can be transmitted between individuals and populations thus threatening the general public health and potentially the economy. Efficient diagnostic tools are needed to provide accurate and timely guidance for case identification, transmission disruption and appropriate treatment administration. Point of care (POC) tests provide actionable results near the patient and thereby serve as a personal "radar". In this review, we review clinical needs for POC testing for several major pathogens, including malaria parasites, human immunodeficiency virus (HIV), human papillomavirus (HPV), dengue, Ebola and Zika viruses and Mycobacterium tuberculosis (TB). We compare different molecular approaches, including pathogen nucleic acid and protein, circulating microRNA and antibodies, used in the POC tests. Finally, we review recent advances in novel POC technologies focusing on microfluidic and plasmonic-based approaches.

PMID:
30853460
PMCID:
PMC6462423
[Available on 2020-06-01]
DOI:
10.1016/j.cca.2019.03.008
[Indexed for MEDLINE]

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