Format

Send to

Choose Destination
Clin Nutr. 2019 Feb 21. pii: S0261-5614(19)30085-8. doi: 10.1016/j.clnu.2019.02.031. [Epub ahead of print]

Longitudinal associations between dietary inflammatory index and musculoskeletal health in community-dwelling older adults.

Author information

1
Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. Electronic address: mavil.cervo@monash.edu.
2
Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
3
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
4
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Faculty of Health, University of Tasmania, Hobart, Tasmania, Australia.
5
Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia; Australian Institute for Musculoskeletal Science, Department of Medicine - Western Health, The University of Melbourne, St Albans, Victoria, Australia.
6
Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Australian Institute for Musculoskeletal Science, Department of Medicine - Western Health, The University of Melbourne, St Albans, Victoria, Australia.

Abstract

BACKGROUND & AIMS:

Aging is characterized by progressive decline in physiologic reserves and functions as well as prolonged inflammation, increasing susceptibility to disease. Diet plays an important role in maintaining health, and reducing morbidity and mortality, especially in older populations. This study was designed to determine prospective associations between dietary inflammatory index (DII®) scores and bone health, sarcopenia-related outcomes, falls risk and incident fractures in community-dwelling Australian older adults.

METHODS:

A total of 1098 [51% male; age (mean ± SD) 63.0 ± 7.5 years] non-institutionalized older adults who participated in the Tasmanian Older Adult Cohort Study (TASOAC) at baseline, 768 at 5 years, and 566 at 10 years follow-up were included in this analysis. Baseline energy-adjusted DII (E-DII) scores were calculated using a validated Food Frequency Questionnaire. Changes in bone mineral density (BMD) and appendicular lean mass (ALM) were measured over ten years using dual-energy x-ray absorptiometry. Ten-year changes in hand grip, knee extensor and whole lower-limb muscle strength and quality were assessed by dynamometers and change in falls risk score using the Physical Profile Assessment (PPA). Incident fractures at any site and non-vertebral fractures over 10 years were self-reported.

RESULTS:

The E-DII range was -3.48 to +3.23 in men and -3.80 to +2.74 in women. Higher E-DII score (indicating a more pro-inflammatory diet) was associated with lower total hip (B: -0.009; 95% CI: -0.017, 0.000) and lumbar spine BMD (B: -0.013; 95% CI: -0.024, -0.002), and higher falls risk score (B: 0.040; 95% CI: 0.002, 0.078) over 10 years in men. Women with higher E-DII scores had higher whole lower-limb muscle quality over 10 years (B: 0.109; 95% CI: 0.002, 0.215). For every unit increase in E-DII score, incident fracture rates increased by 9.0% in men (IRR: 1.090; 95% CI: 1.011, 1.175) and decreased by 12.2% in women (IRR: 0.878; 95% CI: 0.800, 0.964) in a fully adjusted model.

CONCLUSION:

Higher E-DII scores were associated with lower bone density, higher falls risk, and increased incidence of fractures in community-dwelling older men, but decreased fracture incidence in women, over 10 years. This suggests pro-inflammatory diets may be more detrimental to musculoskeletal health in older men than in women. Additional studies are warranted to elucidate these sex differences.

KEYWORDS:

Bone mineral density; Chronic inflammation; Dietary inflammatory index; Falls risk; Fractures; Sarcopenia

PMID:
30852031
DOI:
10.1016/j.clnu.2019.02.031

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center