Format

Send to

Choose Destination
Neuroimage Clin. 2019;22:101732. doi: 10.1016/j.nicl.2019.101732. Epub 2019 Feb 21.

Cortical volume and 40-Hz auditory-steady-state responses in patients with schizophrenia and healthy controls.

Author information

1
Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea; Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
2
Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea.
3
Department of Biomedical Engineering, Chonnam National University, Yeosu, Republic of Korea.
4
Department of Psychiatry, University of Missouri-Kansas City, Kansas City, MO, USA.
5
Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
6
Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea; Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Republic of Korea. Electronic address: lshpss@paik.ac.kr.

Abstract

BACKGROUND:

Abnormalities in the 40-Hz auditory steady-state response (ASSR) of the gamma range have been reported in schizophrenia (SZ) and are regarded as important pathophysiological features. Many of the previous studies reported diminished gamma oscillations in SZ, although some studies reported increased spontaneous gamma oscillations. Furthermore, brain morphological correlates of the gamma band ASSR deficits have rarely examined. We investigated different measures of the 40-Hz ASSR and their association with brain volumes and psychological measures of SZ.

METHODS:

The 40-Hz ASSR was measured for 80 dB click sounds (1 ms, 500-ms trains at 40-Hz, with 3050 to 3500 inter-train interval) using electroencephalography with 64 electrodes in 33 patients with SZ (male: 16, female: 17 (age range: 21-60)) and 30 healthy controls (HCs) (male: 13, female: 17 (age range: 23-64)). Four gamma oscillation measures (evoked power, spontaneous oscillations (baseline and total power), and inter-trial phase coherence (ITC)) were assessed. The source activities of the ASSR were also analyzed. Brain volumes were assessed using high-resolution magnetic resonance imaging and voxel-based morphometry and superior temporal gyrus (STG) volume measures were obtained.

RESULTS:

Patients with SZ had larger total and evoked powers and higher ITC than HCs. Both groups showed significantly different association between mean evoked power and right STG volume. In HCs but not SZ, mean evoked power showed significant positive correlation with right STG volume. In addition, the two groups showed significantly different association between verbal fluency and mean evoked power. High evoked power was significantly correlated with poor verbal fluency in SZ.

CONCLUSIONS:

The current study found increased gamma oscillation in SZ and suggests significant involvement of the STG in gamma oscillations.

KEYWORDS:

40-Hz ASSR; Gamma oscillation; STG volume; Schizophrenia; Voxel-based morphometry

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center