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Addiction. 2019 Mar 9. doi: 10.1111/add.14602. [Epub ahead of print]

RANDOMIZED WITHIN-SUBJECT TRIAL TO EVALUATE SMOKERS' INITIAL PERCEPTIONS, SUBJECTIVE EFFECTS, AND NICOTINE DELIVERY ACROSS SIX VAPORIZED NICOTINE PRODUCTS.

Author information

1
Department of Health Behavior, Roswell Park Cancer Comprehensive Cancer Center, USA.
2
Department of Psychiatry, University at Buffalo, USA.
3
School of Public Health and Health Professions, University at Buffalo, USA.
4
Division of Clinical Pharmacology, Department of Medicine and Bioengineering & Therapeutic Sciences, University of California San Francisco, USA.

Abstract

BACKGROUND AND AIMS:

Vaporized nicotine products (VNPs) can vary in important characteristics including size, shape, flavor, and nicotine yield. We examined whether complex interactions among these characteristics could affect smokers' VNP perceptions and usage patterns.

DESIGN:

A within-subject randomized crossover trial.

SETTING:

Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

PARTICIPANTS:

Eighteen daily cigarette smokers.

MEASUREMENTS:

Participants attended 8 weekly visits during which they sampled six different VNPs (disposable, rechargeable, eGO, mod, e-Cigar, and e-Pipe) with tobacco flavored e-liquid. Prior to device use, participants completed product-ranking questionnaires. Participants completed controlled puffing sessions during each of the six trials, after which satisfaction questionnaires were completed and blood samples were taken.

FINDINGS:

Initial perceptions showed that the smallest device (disposable) was ranked as safer compared with a larger device (e-Pipe) (p<.05). Participants rated the eGO and mod devices higher on satisfaction and enjoyment from use, taste, pleasantness, harshness ("throat hit"), and speed of effect, but lower on perceived health risk and embarrassment from use (p<.05). All devices had a lower Cmax than the combustible cigarette (p<.05), but there were differences among devices (p<.05). The mod, e-Pipe, and eGO provided the highest amount of perceived smoking urge relief, and this correlated strongly with Cmax across all devices (R2 =.8614, p=.007). The perceived speed of urge relief was not correlated with Tmax (R2 =.0035, p=.911) CONCLUSIONS: Daily cigarette smokers testing six types of vaporized nicotine products (VNPs) reported that they varied in taste, amount of withdrawal relief, harshness, embarrassment from use, perceived health risk, and subjective and objective nicotine delivery. The eGO and mod models have properties that may make them most effective for cigarette substitution among smokers who intend to switch to a VNP.

PMID:
30851137
DOI:
10.1111/add.14602

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