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J Biol Chem. 2019 Mar 8;294(10):3367-3368. doi: 10.1074/jbc.H119.007830.

Let's get this pyrin started!

Author information

From the Microbiome and Mucosal Defense Research Unit, Montreal Clinical Research Institute (IRCM), Montréal, Quebec H2W 1R7, Canada,
Department of Medicine, Université de Montréal, Montréal, Quebec H3C 3J7, Canada, and.
Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom


Inflammasomes enable cells to respond to pathogens or biological damage, but the specific signals being used to convey these messages are not always clear. A new paper identifies two potential microbiota-derived metabolites, the bile acid analogues BAA485 and BAA473, as the first small molecules to activate the pyrin inflammasome. These results suggest that microbiota may be able to modulate this inflammatory process which, in turn, may contribute to the maintenance of intestinal homeostasis.

Free PMC Article

Conflict of interest statement

The authors declare that they have no conflicts of interest with the contents of this article.

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