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Surv Ophthalmol. 2019 Mar 5. pii: S0039-6257(18)30192-9. doi: 10.1016/j.survophthal.2019.02.010. [Epub ahead of print]

Corneal keloid presenting forty years after penetrating injury: case report and literature review.

Author information

1
Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
2
Rush Medical College, Chicago, IL, USA.
3
Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA.
4
Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
5
Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: harocopos@vision.wustl.edu.

Abstract

A 64-year-old Caucasian man had been diagnosed with presumed ocular surface squamous neoplasia in the left eye and started on topical interferon alpha 2b drops. When we saw him, he provided a history of penetrating corneal injury more than forty years prior. Slit lamp examination revealed a large, elevated, opaque lesion involving the left cornea. High-definition AS-OCT revealed a hyper-reflective lesion involving the anterior stroma with a relatively normal overlying epithelium. Based on the clinical history, slit lamp, and AS-OCT findings, a giant corneal keloid was suspected, and the interferon drops were discontinued. He subsequently underwent a penetrating keratoplasty, and histopathologic analysis was consistent with corneal keloid. Corneal keloids may be seen decades after the initial trauma, and AS-OCT can be a useful tool in differentiating these tumor-like lesions from other neoplasia.

KEYWORDS:

anterior segment ocular coherence tomography; cornea; histopathology; immunohistochemical staining; keloid; ocular surface squamous neoplasia

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