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Surv Ophthalmol. 2019 Mar 5. pii: S0039-6257(18)30192-9. doi: 10.1016/j.survophthal.2019.02.010. [Epub ahead of print]

Corneal keloid presenting forty years after penetrating injury: case report and literature review.

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Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Rush Medical College, Chicago, IL, USA.
Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA.
Department of Ophthalmology and Visual Sciences, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:


A 64-year-old Caucasian man had been diagnosed with presumed ocular surface squamous neoplasia in the left eye and started on topical interferon alpha 2b drops. When we saw him, he provided a history of penetrating corneal injury more than forty years prior. Slit lamp examination revealed a large, elevated, opaque lesion involving the left cornea. High-definition AS-OCT revealed a hyper-reflective lesion involving the anterior stroma with a relatively normal overlying epithelium. Based on the clinical history, slit lamp, and AS-OCT findings, a giant corneal keloid was suspected, and the interferon drops were discontinued. He subsequently underwent a penetrating keratoplasty, and histopathologic analysis was consistent with corneal keloid. Corneal keloids may be seen decades after the initial trauma, and AS-OCT can be a useful tool in differentiating these tumor-like lesions from other neoplasia.


anterior segment ocular coherence tomography; cornea; histopathology; immunohistochemical staining; keloid; ocular surface squamous neoplasia

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