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Mol Cell. 2019 Mar 7;73(5):863-865. doi: 10.1016/j.molcel.2019.01.039.

Sequencer Hacking Unlocks Quantitative Protein Studies.

Author information

1
Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
2
Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute; Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: selledge@genetics.med.harvard.edu.

Abstract

In this issue of Molecular Cell, Layton et al. (2019) repurpose a common next-generation DNA sequencer to enable high-throughput protein biochemical studies, identifying improved sequence variants for stronger protein-protein interactions and dissecting the contributions of specific amino acids to enzymatic activity.

PMID:
30849392
DOI:
10.1016/j.molcel.2019.01.039
[Indexed for MEDLINE]

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