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Cell Stem Cell. 2019 Mar 7;24(3):351-352. doi: 10.1016/j.stem.2019.02.008.

FOXO3, a Molecular Search for the Fountain of Youth.

Author information

1
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. Electronic address: w.e.fibbe@lumc.nl.
2
The First Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University Medical College, Suzhou, Jiangsu 215123, China. Electronic address: shiyufang2@gmail.com.

Abstract

FOXO3 has been consistently associated with longevity and with a reduction in the prevalence of cardiovascular disease. In this issue, Yan et al. (2019) report that FOXO3-activated vascular cells derived from human embryonic stem cells (ESCs) promote multiple vascular functions and reverse cellular aging through the transcriptional repression of CSRP1.

PMID:
30849363
DOI:
10.1016/j.stem.2019.02.008

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