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J Endocrinol Invest. 2019 Mar 7. doi: 10.1007/s40618-019-01031-8. [Epub ahead of print]

Vitamin D status and non-alcoholic fatty liver disease in patients with type 1 diabetes.

Author information

1
Division of Metabolic Diseases, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy.
2
, Solagna, Italy.
3
Department of Medicine, Clinica Medica 1, University of Padova, Padova, Italy.
4
Division of Metabolic Diseases, Department of Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy. daniela.bruttomesso@unipd.it.

Abstract

PURPOSE:

In patients with type 1 diabetes (T1D), the prevalence of non-alcoholic fatty liver disease (NAFLD) ranges from 10 to 53% and contrasting evidence suggests that vitamin D deficiency may favor liver fat accumulation. Here, we investigated the association between vitamin D status and NAFLD in adults with T1D.

METHODS:

220 consecutive adult T1D patients on multiple daily injections or continuous subcutaneous insulin infusion and not taking calcium or vitamin D supplements were included. Patient characteristics, 25(OH)D serum levels, and metabolic parameters were analyzed. Vitamin D status was defined as sufficiency ( ≥ 75 nmol/L; 30 ng/ml), insufficiency (50-75 nmol/L; 20-30 ng/ml), or deficiency ( < 50 nmol/L; 20 ng/ml). NAFLD was diagnosed at ultrasound examination and graded 0-3.

RESULTS:

NAFLD was present in 57 patients (29.5%): 51 grade 1, 5 grade 2, and 1 grade 3. Median 25(OH)D levels were 53 nmol/L (IQR 38-70) in patients with NAFLD and 50 nmol/L (34-69) in patients without (p = 0.46). At multivariable analysis, NAFLD was not associated with 25(OH)D levels (p = 0.42) or vitamin D deficiency (p = 0.55), while BMI (OR 1.16, 95% CI 1.07-1.27) and serum triglycerides (OR 1.02, 95% CI 1.01-1.03) were independently associated with NAFLD.

CONCLUSIONS:

Vitamin D status appears to have no link with low-grade NAFLD in patients with type 1 diabetes.

KEYWORDS:

Non-alcoholic fatty liver disease (NAFLD); Type 1 diabetes; Ultrasound; Vitamin D

PMID:
30847862
DOI:
10.1007/s40618-019-01031-8

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