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Food Sci Nutr. 2019 Jan 25;7(2):369-384. doi: 10.1002/fsn3.903. eCollection 2019 Feb.

Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations.

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Department of Biology College of Science University of Bahrain Zallaq Bahrain.
Department of Public Health, Experimental and Forensic Medicine Section of Human Nutrition, Endocrinology and Nutrition Unit Azienda di Servizi alla Persona University of Pavia Pavia Italy.
Department of Earth and Environmental Sciences Mycology and Plant Pathology Laboratory Pavia Italy.
Research and Development Unit Indena Milan Italy.
Department of Biomedical Science and Human Oncology University of Bari Bari Italy.
IRCCS Mondino Foundation Pavia Italy.


We summarize the effects of bergamot (extract, juice, essential oil, and polyphenolic fraction) on cardiovascular, bone, inflammatory, skin diseases, mood alteration, anxiety, pain, and stress. This review included a total of 31 studies (20 studies on humans with 1709 subjects and 11 in animals (rats and mice)). In humans, bergamot-derived extract (BE) exerts positive effects on hyperlipidemia with an oral dose from 150 mg to 1000 mg/day of flavonoids administered from 30 to 180 days, demonstrating an effect on body weight and in modulating total cholesterol, triglycerides, LDL, and HDL. Studies in animals confirm promising data on glucose control (500/1000 mg/day of BE with a treatment lasting 30 days) are available in rats. In animals models, bergamot essential oil (BEO, 10 mg/kg or 20 mg/kg daily for 20 weeks) increases bone volume, decreases psoriatic plaques, increases skin collagen content, and promotes hair growth. Bergamot juice (20 mg/kg) is promising in terms of pro-inflammatory cytokine reduction. In humans, aromatherapy (from 15 to 30 min) does not appear to be useful in order to reduce stress, anxiety, and nausea, compared to placebo. Compared to baseline, BE topical application and BEO aromatherapy reduce blood diastolic and systolic pressure and could have a significant effect on improving mental conditions.


bergamot; bone; cardiovascular; diabetes; inflammation; skin

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The authors declare that they do not have any conflict of interest.

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