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J Neurol Neurosurg Psychiatry. 2019 Mar 7. pii: jnnp-2018-319723. doi: 10.1136/jnnp-2018-319723. [Epub ahead of print]

Gait worsening and the microlesion effect following deep brain stimulation for essential tremor.

Author information

1
Center for Movement Studies, Kennedy Krieger Institute, Baltimore, Maryland, USA rroemmi1@jhmi.edu.
2
Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
3
School of Kinesiology, Auburn University, Auburn, Alabama, USA.
4
Department of Neuroscience, University of Florida, Gainesville, Florida, USA.
5
J. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA.
6
Department of Neurology, University of Florida, Gainesville, Florida, USA.
7
Center for Movement Disorders, Gainesville, Florida, USA.
8
Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, USA.
9
Department of Neurosurgery, University of Florida College of Medicine, Gainesville, USA.
10
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, USA.

Abstract

OBJECTIVE:

To investigate the effects of unilateral thalamic deep brain stimulation (DBS) on walking in persons with medication-refractory essential tremor (ET).

METHODS:

We performed laboratory-based gait analyses on 24 persons with medication-refractory ET before and after unilateral thalamic DBS implantation. Normal and tandem walking parameters were analysed across sessions (PRE-DBS/DBS OFF/DBS ON) by repeated measures analyses of variance. Pearson's correlations assessed whether changes in walking after DBS were global (ie, related across gait parameters). Baseline characteristics, lead locations and stimulation parameters were analysed as possible contributors to gait effects.

RESULTS:

DBS minimally affected gait at the cohort level. However, 25% of participants experienced clinically meaningful gait worsening. Walking speed decreased by >30% in two participants and by >10% in four others. Decreased walking speed correlated with increased gait variability, indicating global gait worsening in affected participants. The worsening persisted even after the stimulation was turned off. Participants with worse baseline tandem walking performance may be more likely to experience post-DBS gait worsening; the percentage of tandem missteps at baseline was nearly three times higher and tandem walking speeds were approximately 30% slower in participants who experienced gait worsening. However, these differences in tandem walking in persons with gait worsening as compared with those without worsening were not statistically significant. Lead locations and stimulation parameters were similar in participants with and without gait worsening.

CONCLUSION:

Global gait worsening occurred in 25% of participants with unilateral DBS for medication-refractory ET. The effect was present on and off stimulation, likely indicating a microlesion effect.

PMID:
30846538
DOI:
10.1136/jnnp-2018-319723

Conflict of interest statement

Competing interests: None declared.

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