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Trends Microbiol. 2019 Mar 4. pii: S0966-842X(19)30021-6. doi: 10.1016/j.tim.2019.01.008. [Epub ahead of print]

Commensal Staphylococci Influence Staphylococcus aureus Skin Colonization and Disease.

Author information

1
University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Department of Microbiology, Iowa City, IA, USA.
2
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
3
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Veterans Affairs Eastern Colorado Healthcare System, Aurora, CO, USA. Electronic address: alexander.horswill@ucdenver.edu.

Abstract

Commensal organisms that constitute the skin microbiota play a pivotal role in the orchestration of cutaneous homeostasis and immune competence. This balance can be promptly offset by the expansion of the opportunistic pathogen Staphylococcus aureus, which is responsible for the majority of bacterial skin infections. S. aureus carriage is also known to be a precondition for its transmission and pathogenesis. Recent reports suggest that skin-dwelling coagulase-negative staphylococci (CoNS) can prime the skin immune system to limit the colonization potential of invaders, and they can directly compete through production of antimicrobial molecules or through signaling antagonism. We review recent advances in these CoNS colonization resistance mechanisms, which may serve to aid development of pharmacologic and probiotic intervention strategies to limit S. aureus skin colonization and disease.

KEYWORDS:

MRSA; Staphylococcus aureus; colonization; host protection; quorum sensing; skin microbiota

PMID:
30846311
DOI:
10.1016/j.tim.2019.01.008

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