Format

Send to

Choose Destination
BMC Cardiovasc Disord. 2019 Mar 7;19(1):55. doi: 10.1186/s12872-019-1040-4.

Hypercoagulability and the risk of recurrence in young women with myocardial infarction or ischaemic stroke: a cohort study.

Author information

1
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
2
Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Università degli Studi di Milano, Milan, Italy.
3
Department of Internal Medicine, Azienda Provinciale per i Servizi Sanitari, Trento, Italy.
4
Department of Neurology and Neurosurgery, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
5
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
6
Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, The Netherlands.
7
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. bob.siegerink@charite.de.
8
Center for Stroke research Berlin, Charité Universitätsmedizin, Center for Stroke Research, Chariteplatz 1, 10117, Berlin, Germany. bob.siegerink@charite.de.

Abstract

BACKGROUND:

We aimed to investigate the role of hypercoagulability on the risk of lifetime cardiovascular recurrences after myocardial infarction or ischaemic stroke.

METHODS:

Young women (< 50 years) with either myocardial infarction (n = 197) or ischaemic stroke (n = 107) were followed between 1995 and 2012 in the RATIO follow-up study. To determine whether hypercoagulability affects the risk or recurrence, a coagulation score based on acquired and inherited markers was compiled and used in a quartile analysis. Hazard ratios (HRs) obtained from Cox proportional models and adjusted for several cardiovascular risk factors were used to compare quartiles of the coagulation score for the risk of recurrence.

RESULTS:

During a median follow-up of 19 years, 59 cardiovascular recurrences occurred. In patients with myocardial infarction no association was found between a high prothrombotic score and recurrences (highest quartile vs lowest quartile HR 0.7, 95% CI, 0.3-1.8). Conversely, ischaemic stroke patients with a high prothrombotic score showed a doubling in risk of long-term cardiovascular recurrences (HR 1.9, 95% CI 0.6-6.3) compared with ischaemic stroke patients and low levels of the score, with a dose response relationship.

CONCLUSIONS:

An increased coagulation tendency might be associated with long-term cardiovascular risk in women with ischaemic stroke, but not in women with myocardial infarction.

KEYWORDS:

Myocardial infarction; Prognosis; Recurrences; Stroke in young adults; Thrombosis

PMID:
30845907
DOI:
10.1186/s12872-019-1040-4
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center