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Int J Mol Sci. 2019 Mar 6;20(5). pii: E1153. doi: 10.3390/ijms20051153.

Abdominal Fat SIRT6 Expression and Its Relationship with Inflammatory and Metabolic Pathways in Pre-Diabetic Overweight Patients.

Author information

1
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", via L. De Crecchio 7, 80138 Naples, Italy. nunzia.donofrio@unicampania.it.
2
Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. dott.goriziopieretti@gmail.com.
3
Breast Unit and Plastic Surgery, Villa dei Fiori Hospital, 80011 Naples, Italy. giovannifrancesco.nicoletti@unicampania.it.
4
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. antonio.gambardella@unicampania.it.
5
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. nicola.passariello@unicampania.it.
6
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. mariarosaria.rizzo@unicampania.it.
7
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. michelangela.barbieri@unicampania.it.
8
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. raffaele.marfella@unicampania.it.
9
Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. feliciano.ciccarelli@libero.it.
10
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", via L. De Crecchio 7, 80138 Naples, Italy. marialuisa.balestrieri@unicampania.it.
11
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy. celestino.sardu@unicampania.it.

Abstract

: The role of sirtuin 6 (SIRT6) in adipose abdominal tissue of pre-diabetic (pre-DM) patients is poorly known. Here, we evaluated SIRT6 expression in visceral abdominal fat of obese pre-diabetic patients and the potential effects of metformin therapy. Results indicated that obese pre-DM subjects showed low SIRT6 protein expression and high expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), peroxisome proliferator-activated receptor gamma (PPAR-γ), and sterol regulatory element-binding transcription factor 1 (SREBP-1). Obese pre-DM patients showed high values of glucose, insulin resistance (HOMA-IR), C reactive protein (CRP), nitrotyrosine, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6), and low values of insulin (p < 0.05). Of note, abdominal fat tissue of obese pre-DM patients treated with metformin therapy presented higher SIRT6 expression and lower NF-κB, PPAR-γ, and SREBP-1 expression levels compared to pre-DM control group. Collectively, results show that SIRT6 is involved in the inflammatory pathway of subcutaneous abdominal fat of obese pre-DM patients and its expression responds to metformin therapy.

KEYWORDS:

NF-κB; PPAR-γ; SREBP-1; obesity; pre-diabetes; sirtuin 6

PMID:
30845774
DOI:
10.3390/ijms20051153
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