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Int J Cosmet Sci. 2019 Jun;41(3):213-220. doi: 10.1111/ics.12523. Epub 2019 May 6.

Potentially beneficial effects of rhamnose on skin ageing: an in vitro and in vivo study.

Author information

1
L'Oréal Research and Innovation, L'Oréal, 1 avenue Eugène Schueller, 93360, Aulnay-sous-Bois, France.

Abstract

in English, French

OBJECTIVE:

Recent findings showed that skin ageing preferentially affects human papillary dermal fibroblasts suggesting that the papillary dermis represents a critical zone altered by skin ageing. Based on these findings, we investigated the potential anti-ageing effect of rhamnose.

METHODS:

We investigated the potential anti-ageing effect of rhamnose using in vitro reconstructed skin containing fibroblasts obtained either from young or old donors, and in vivo clinical investigation.

RESULTS:

We detected positive effects of rhamnose in both epidermal and dermal compartments of in vitro reconstructed skin. Moreover, we were able to show that such in vitro findings were also obtained in vivo including an effect on collagen IV and procollagen I production.

CONCLUSION:

We provide evidence that rhamnose has a potentially beneficial effect on papillary dermis and dermal-epidermal junction, both of the areas which are affected by skin ageing.

KEYWORDS:

ageing; papillary dermis; rhamnose

PMID:
30845349
DOI:
10.1111/ics.12523

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