Send to

Choose Destination
AIDS. 2019 Mar 5. doi: 10.1097/QAD.0000000000002184. [Epub ahead of print]

T and B-cell perturbations identify distinct differences in HIV-2 compared with HIV-1 induced immunodeficiency.

Author information

Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
Department of Clinical Immunology, Aarhus University Hospital, Denmark.
Department of Infectious Diseases, Aarhus University Hospital, Denmark.
National HIV Programme, Ministry of Health, Bissau, Guinea-Bissau, National Public Health Laboratory, Bissau, Guinea-Bissau.
GloHAU, Center for Global Health, School of Public Health, Aarhus University, Denmark.
Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Denmark.



For unknown reasons, HIV-2 is less pathogenic than HIV-1, and HIV-2 induced immunodeficiency may be different from that caused by HIV-1. Previous immunological studies have hinted at possible shifts in both T and B-cell subsets, which we aimed to characterize further.


From an HIV clinic in Guinea-Bissau, 63 HIV-2, 83 HIV-1, and 26 HIV negative participants were included. All HIV infected participants were ART naïve. The following cell subsets were analysed by flow cytometry; T cells (maturation and activation), regulatory T cells, and B cells (maturation and activation).


After standardizing for sex, age, and CD4+ T cell count HIV-2 had 0.938 log10 copies/mL lower HIV RNA levels than the HIV-1 infected patients. Whereas T-cell maturation and regulatory T-cell profiles were similar between patients, HIV-2 infected patients had higher proportions of CD8+CD28+ and lower proportions of CD8+PD-1+ T cells than HIV-1 infected patients. This finding was independent of HIV RNA levels. HIV-2 was also associated with a more preserved proportion of naïve B cells.


HIV-2 is characterized by lower viral load, and lower T-cell activation, which may account for the slower disease progression.

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center