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Allergy. 2019 Mar 6. doi: 10.1111/all.13762. [Epub ahead of print]

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice.

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Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Asagi Saito, Ibaraki-city, Osaka, 567-0085, Japan.
Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe-city, Hyogo, 650-0017, Japan.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-1 Yamadaoka, Suita-city, Osaka, 565-0871, Japan.
Nippon Flour Mills Co., Ltd, Innovation Center, 5-1-3 Midorigaoka, Atsugi, Kanagawa, 243-0041, Japan.
Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawara-cho, Kyoto, 606-8507, Japan.
Laboratory of Proteome Research, NIBIOHN, 7-6-8 Asagi Saito, Ibaraki-city, Osaka, 567-0085, Japan.
International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohata, Chuo-ku, Chiba-city, Chiba, 260-8670, Japan.
Division of Gastroenterology, Department of Medicine, University of California, San Diego (UCSD), CA, USA.
CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines (cMAV), UCSD, San Diego, CA, USA.
Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry, Osaka University, 1-1 Yamadaoka, Suita-city, Osaka, 565-0871, Japan.


Coconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol and provides instant energy. Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown. In this study, we showed the impact of dietary coconut oil in allergic skin inflammation by using a mouse model of contact hypersensitivity (CHS). Mice maintained on coconut oil showed amelioration of skin inflammation and increased levels of cis-5, 8, 11-eicosatrienoic acid (mead acid) in serum. Intraperitoneal injection of mead acid inhibited CHS and reduced the number of neutrophils infiltrating the skin. Detailed mechanistic studies unveiled that mead acid inhibited the directional migration of neutrophils by inhibiting the filamentous actin polymerization and leukotriene B4 production required for secondary recruitment of neutrophils. Our findings provide valuable insights into the preventive roles of coconut oil and mead acid against skin inflammation, thereby offering attractive therapeutic possibilities. This article is protected by copyright. All rights reserved.


LTB 4 ; Coconut oil; Mead acid; Neutrophils; Skin inflammation


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