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J Perinatol. 2019 Mar 6. doi: 10.1038/s41372-019-0345-6. [Epub ahead of print]

In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation.

Author information

1
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan/Wayne State University, Detroit, MI, USA. pagarwal@dmc.org.
2
Department of Radiology, Children's Hospital of Michigan, Detroit, MI, USA.
3
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.
4
Department of General Surgery, Children's Hospital of Michigan, Detroit, MI, USA.
5
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Hospital of Michigan/Wayne State University, Detroit, MI, USA.

Abstract

OBJECTIVE:

To determine in-hospital outcomes of neonates with hypoxic ischemic encephalopathy (HIE) requiring extracorporeal membrane oxygenation (ECMO).

STUDY DESIGN:

Single-center retrospective study from 2005 to 2016 of neonates ≥35 weeks gestation with moderate/severe HIE, requiring ECMO for persistent pulmonary hypertension of newborn (PPHN).

RESULTS:

Our cohort (n = 20) received therapeutic hypothermia for moderate (n = 12), severe (n = 5), or undocumented severity (n = 3) of HIE. During ECMO, 30% (n = 6) infants developed intracranial hemorrhage at a median (IQR) duration of 24 (20) hours. Sixteen (80%) infants survived to discharge, among which 15 had MRI performed; 47% (n = 7) had normal MRI, 20% (n = 3) had intracranial hemorrhage and 13% (n = 2), 13% (n = 2) and 7% (n = 1) had NICHD stage 1, 2, and 3 pattern of brain injury respectively.

CONCLUSIONS:

In this high-risk population of neonates, use of ECMO was safe and efficacious as demonstrated by survival and outcomes.

PMID:
30842551
DOI:
10.1038/s41372-019-0345-6

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