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FASEB J. 2019 Mar 6:fj201802727R. doi: 10.1096/fj.201802727R. [Epub ahead of print]

Sleep deprivation and a non-24-h working schedule lead to extensive alterations in physiology and behavior.

Author information

1
Ministry of Education (MOE) Key Laboratory of Gene Function and Regulation, School of Life Sciences, State Key Laboratory of Biocontrol, and.
2
Guangdong Jiangmen Chinese Traditional Medicine College, Jiangmen, China; and.
3
Eighth Medical Center, General Hospital of Chinese People's Liberation Army, Beijing, China.
4
Reproductive Medicine Center, First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, China.
5
Sixth Medical Center, General Hospital of Chinese People's Liberation Army, Beijing, China.

Abstract

Most organisms on Earth possess circadian rhythms in their physiology and behaviors that allow them to resonate with the cycling environment over a 24-h period. However, in human society, a substantial quantity of jobs requires non-24-h working and rest or shift schedules, which causes more or less misalignment in circadian rhythms and disorders as a consequence. In this work, we conducted a sleep deprivation (SD) and non-24-h working and rest schedule (8 h on and 4 h off) experiment over 10 d in total and measured the changes in a series of physiologic and cognitive parameters. The results show that although the subjects could sleep during the schedule, their sleepiness increased significantly. Actigraphy data suggest that a 12-h schedule might result in chronic SD. Along with the increased sleepiness revealed by the Karolinska Sleepiness Scale questionnaire, the neurobehavioral psychomotor vigilance test data reveal that, compared with the control period, the reaction time of the subjects was significantly delayed. The saliva insulin levels were significantly changed in the morning in SD and non-24-h cycles. Salivary biochemical parameters were also altered, including aspartate aminotransferase and K+. 16S rRNA-based analysis of the salivary microbiota showed differentially changed patterns in bacteria composition and concentration. Together, these data demonstrate that an abnormal working and rest schedule might produce comprehensive interference with circadian rhythms, metabolism, and cognition.-Ma, H., Li, Y., Liang, H., Chen, S., Pan, S., Chang, L., Li, S., Zhang, Y., Liu, X., Xu, Y., Shao, Y., Yang, Y., Guo, J. Sleep deprivation and a non-24-h working schedule lead to extensive alterations in physiology and behavior.

KEYWORDS:

circadian rhythms; cognition; hormone; salivary microbiota

PMID:
30841753
DOI:
10.1096/fj.201802727R

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