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Biomed Pharmacother. 2019 Mar;111:1013-1021. doi: 10.1016/j.biopha.2019.01.003. Epub 2019 Jan 10.

Daphnoretin: An invasion inhibitor and apoptosis accelerator for colon cancer cells by regulating the Akt signal pathway.

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First Department of Colorectal Surgery, The Third Hospital of Hebei Medical University, Shijiazhang, 050000, China.
Pharmacy Department, The Third Hospital of Hebei Medical University, Shijiazhang, 050000, China. Electronic address:
ICU of Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhang, China.


The regulation of Daphnoretin on specific tumours (e.g. cervical cancer, lung cancer, osteosarcoma) has been documented, which still remains unclear for colon cancer cells. Our study explored the suppression of Daphnoretin and its molecular mechanism on the proliferation, apoptosis, invasion and migration of human colon cancer cell line HCT116. Our report showed the activity of HCT116 declined with time- and dose- dependence after Daphnoretin intervention, and a rise in G0/G1 ratio and decrease in G2/M ratio was observed. Daphnoretin-treated HCT116 had declined invasion and migration, increased apoptosis rate, and variations in gene expressions related to the Akt signal pathway. Those results indicated that Daphnoretin can inhibit the proliferation, invasion, and migration of HCT116 and promote its apoptosis by regulating the activity of Akt signal pathway.


AKT signal pathway; Apoptosis; Colon cancer; Daphnoretin; Invasion

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